朱雄,藥物化學博士,伟德官网下载客户端伟德官网下载客户端研究員,博士生導師,醫藥化工研究所所長。兼任世界中聯兒童醫藥健康産品産業會常務理事,世界中聯經皮給藥委員會常務理事等。南京領軍型科技創業企業家,南京“創新型企業家培育計劃”人才。
近年來主要從事創新性小分子藥物研究開發工作,先後主持承擔各類科研項目數十項,包括國家“重大新藥創制”科技重大專項2項、江蘇省、福建省科技重大項目數項和多項橫向開發項目,具有新藥研發及産業化三十餘年經驗,為社會創造了數十億的産值。獲得國家各類新藥證書15本,新藥臨床批件13件;申請國内外發明專利20餘項,在國内外核心刊物上發表論文30餘篇。開發的國家1.1類創新藥去氧鬼臼毒素目前處于I期臨床研究階段,已成功進行商業化授權,該工作于2020年獲評2019年度江蘇省科學技術一等獎。
研究方向:
1. 抗菌藥物、抗糖尿病藥物、心腦血管藥物和抗腫瘤藥物的設計與合成研究;
2. 候選化合物的成藥性評價;
3. 國外上市新藥的創新工藝研究。
聯系方式:025-83355763 Email:cpuzx@foxmail.com
近期5篇代表性論文:
1. Shangde Liu, Duo Yuan, Shanshan Li, Roujie Xie, Yi Kong, Xiong Zhu*. Synthesis and evaluation of novel and potent protease activated receptor 4 (PAR4) antagonists based on a quinazolin-4(3H)-one scaffold. European Journal of Medicinal Chemistry, 2021, 225, 113764.
2. Shangde Liu, Shanshan Li, Duo Yuan, Enmao Wang, Roujie Xie, Weiqi Zhang, Yi Kong, Xiong Zhu*.Protease activated receptor 4 (PAR4) antagonists: Research progress on small molecules in the field of antiplatelet agents. European Journal of Medicinal Chemistry, 2021, 209, 112893.
3. Qiyang Yin, Bo Zhao, Jianping Zhu, Yuxiang Fei, Weiyang Shen, Bingwen Liang, Xiong Zhu*, Yuman Li*. JLX001 improves myocardial ischemia-reperfusion injury by activating Jak2-Stat3 pathway. Life Sciences, 2020, 257, 118083.
4. Bo Zhao, Jianping Zhu, Yuxiang Fei, Qiyang Yin, Weiyang Shen, Bingwen Liang, Xiong Zhu*, Yunman Li*. JLX001 attenuates blood-brain barrier dysfunction in MCAO/R rats via activating the Wnt/β-catenin signaling pathway. Life Sciences, 2020, 260, 118221.
5. Luyao Ao, Wanting Li, Lin Zhou, Yunyi Yan, An-qi Ye, Bing-wen Liang, Wei-yang Shen, Xiong Zhu*, Yun-man Li*. Therapeutic effects of JLX-001 on ischemic stroke by inducing autophagy via AMPK-ULK1 signaling pathway in rats. Brain Research Bulletin, 2019, 153, 162-170.