楊靜,女,博士,特聘副研究員,碩士研究生導師。2017年畢業于蘇州大學藥學院,獲得醫學博士學位。2014-2017為蘇州大學-哈佛大學麻省總醫院聯合培養博士,2017-2019哈佛大學麻省總醫院博士後。2020年10月加入伟德官网下载客户端伟德官网下载客户端生物醫學工程教研室。目前主持有伟德官网下载客户端高層次人才引進項目1項(100萬)。近年來在Nature Communications, Chemical Science, Chemical Communications等國際權威期刊發表論文20餘篇。

 

聯系方式:yangjing@cpu.edu.cn

 

研究方向:

1. 小分子光學探針的構建及在AD診療中的應用

2. 抗腫瘤蛋白降解藥物分子的設計及活性研究

3. 棕色脂肪的成像研究

 

代表性論文:

 

1. Jing Yang#, Wei Yin#, Richard Van, Keyi Yin, Peng Wang, Chao Zheng, Biyue Zhu, Kathleen Ran, Can Zhang, Mohanraja Kumar, Yishan Shao, Chongzhao Ran. Turn-on chemiluminescence probes and dual-amplification of signal for detection of amyloid beta species in vivo. Nature Communications, 2020, 11(1), 1-14.

 

2. Jing Yang#, Biyue Zhu#, Wei Yin, Zhihao Han, Chao Zheng, Peng Wang, Chongzhao Ran. Differentiating Ab40 and Ab42 in amyloid plaques with a small molecule fluorescence probe. Chemical Science, 2020, 11 (20), 5238-5245.

 

3. Jing Yang#, Jian Yang#, Huan Wang, Junfeng Wang, Jianping Xiong, Chunhua Qiao, Chongzhao Ran.. Atom-economical design of PET tracer for imaging αvβ3 integrin via utilizing three-in-one function of 64Copper. Chemical Communications, 2020, 56 (12), 1788-1791.  

 

4. Jian Yang#, Jing Yang#, Yuyan Li, Yungen Xu,  Ran, C. Z. Near-infrared Fluorescence Ocular Imaging (NIRFOI) of Alzheimer’s Disease. Molecular Imaging and Biology, 2019, 21 (1), 35-43. 

 

5. Liguo Wang, Jing Yang*, Huan Wang, Chongzhao Ran, Ying Su, Long Zhao*. A highly selective turn-on fluorescent probe for the detection of aluminum and its application to bio-imaging. Sensors2019, 19 (11), 1-10.

 

6. Jing Yang, Jian Yang, Chongzhao Ran. Spectral Unmixing Imaging for Differentiating Brown Adipose Tissue Mass and Its Activation. Contrast Media & Molecular Imaging, 2018, 2018, 1-7.

 

7. Jing Yang#, Xueli Zhang#, Yiying Zhu, Emily Lenczowski, Yanli Tian, Jian Yang, Can Zhang, Markus Hardt, Chunhua Qiao, Rudolph E. Tanzi, Anna Moore, Hui Ye, Chongzhao Ran. A double-edged role of copper in the fate of amyloid beta in the presence of anti-oxidants. Chemical Science, 2017, 8 (9), 6155-6164.

 

 

8. Jing Yang, Zhengtao Tu, Xin Xu, Jinfeng Luo, Xing Yan, Chongzhao Ran, Xinliang Mao, Ke Ding, Chunhua Qiao. Novel Conjugates of Endoperoxide and 4-Anilinoquinazoline as Potent Anticancer AgentsBioorganic & Medicinal Chemistry Letters, 2017, 27 (6), 1341-1345.

 

9. Jing Yang#, Jian Yang#, Lu Wang, Anna Moore, Steven. H Liang, Chongzhao Ran. Yang, J., Yang, J., Wang, L., Moore, A., Liang, S. H., Ran, C. Z. Synthesis-free PET imaging of brown adipose tissue and TSPO via combination of disulfiram and 64CuCl2. Scientific Reports, 2017, 7, 1-9.

 

10. Jing Yang, Yanli Liu, Chengwen Xue, Wei Yu, Jian Zhang, Chunhua Qiao. Synthesis and biological evaluation of glaucocalyxin A derivatives as potential anticancer agents. European Journal of Medicinal Chemistry, 2014, 86, 235-241.

 

11. Huanqiu Li#, Jing Yang#, Shuhua Ma, Chunhua, Qiao. Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. Bioorganic & Medicinal Chemistry, 2012, 20 (14), 4194-4200.

             注:# Equal contribution

 


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