生物與醫藥(專碩、專博)


陳維
教授
院系:伟德官网下载客户端制藥與環境工程系
招生方向:制藥工程學,生物與醫藥
實驗室:實驗樓A樓110
電子郵箱:w.chen@cpu.edu.cn
辦公室:實驗樓A樓110
個人簡介

   陳維,博士,教授,博士生導師,新型微納藥物實驗室負責人。2018年入選江蘇特聘教授, 近年來多次入選美國斯坦福大學發布的全球前2%頂尖科學家。2013年荷蘭特文特大學(University of Twente)高分子化學與生物材料專業獲博士學位;2013-2017年德國柏林自由大學(Freie Universität Berlin)博士後研究,并榮獲德國洪堡學者。目前已在化學、藥學、生物材料學等領域國際知名學術期刊如:Angew. Chem. Int. Ed.Adv. Funct. Mater.APSBJ. Control. ReleaseBiomaterialsNano Today等發表論文70餘篇,論文引用3500餘次。目前已申請或授權的歐洲、美國專利和中國專利30餘項,主持多項省部級、校級和企業轉化科研項目。

研究方向

   智能型可降解微納藥物、功能性生物材料合成加工、藥效分子高效分離提取

承擔項目情況

面上項目,國家自然科學基金委,促進血腦屏障跨越及藥物深層滲透的兩性離子型NO供體納米藥物用于腦腫瘤的靶向聯合治療2025.01-2028.12

面上項目,國家自然科學基金委,生物響應性小尺寸兩性離子納米藥物促進腫瘤高效富集與滲透及對幹細胞的治療,2022.01-2025.12

面上項目,國家自然科學基金委,含一氧化氮供體的生物可降解可逆交聯膠束介導前列腺癌靶向協同治療,2020.01-2023.12

青年項目,國家自然科學基金委,腫瘤高靶向的不對稱膜結構的兩性離子聚合物囊泡用于蛋白質藥物的高效包裹和控制釋放,2018.01-2021.01

青年項目,江蘇省自然科學基金委,低免疫原性的不對稱膜結構的聚合物囊泡用于蛋白質藥物的高效包封與腫瘤靶向治療,2017.07-2020.07。

代表性科研成果

1. J.M. Zhang, G.Z. Miao, M.H. Ta, B.B. Zhao, W. Wang, Y.R. Xing, H.L. Qian, D.C. Huang*, W. Chen*, Y.N. Zhong*, Photothermal-controlled NO-releasing Nanogels Reverse Epithelial-mesenchymal Transition and Restore Immune Surveillance against Cancer Metastasis, J. Control. Release 2024, 371, 16-28.

2. L.L. Gao, Z.Y. Yuan, N.Y. Ma, X. Zhou, X. Huang, W. Chen*, H.S. Qiao*, Nitric Oxide Polymersome-Immobilized Hydrogels for Prevention of Post-surgical Tumor Recurrence and Metastasis, Chem. Eng. J. 2024, 485, 149688.

3. Y.H. Ma, C.H. Li, F.W. Han, Y.Z. Liu, U.E. Hani, Y.N. Zhong, D.C. Huang*, W. Chen*, H.L. Qian*, Oral Delivery Of Berberine by Liver-Targeted Zwitterionic Nanoparticles to Overcome Multi-Intestinal Barriers and Extend Insulin Treatment Duration, Chem. Eng. J. 2024, 485, 150129.

4. K. Wang#, B.B. Zhao#, Y.L. Ao, J.Y. Zhu, C.S. Zhao, W. Wang, Y. Zou, D.C. Huang*, Y.N. Zhong, W. Chen*, H.L. Qian*, Super-small Zwitterionic Micelles Enable the Improvement of Blood-brain Barrier Crossing for Efficient Orthotopic Glioblastoma Combinational Therapy, J. Control. Release 2023, 364, 261-271.

5. Y.F. Li#, H.L. Qian#, X. Huang#, X. Zhou, B.B. Zhao, L.F. Yang, J.X. Chen, H.S. Qiao, D.C. Huang*, Y.N. Zhong*, W. Chen*, Up-Converted Nano-Gasholder with Precise Nitric Oxide Release Remodels Immunosuppressive Microenvironment and Potentiates Tumor Immunotherapy, Nano Today 2022, 42, 101381.

6. H.L. Qian#, K. Wang#, M.T. Lv, C.S. Zhao, H. Wang, S.C. Wen, D.C. Huang*, W. Chen*, Y.N. Zhong*, Recent Advances on Next Generation of Polyzwitterion-based Nano-Vectors for Targeted Drug Delivery, J. Control. Release 2022, 343, 492-505.

7. Z.H. Liu#, Y.N. Zhong#, X. Zhou, X. Huang, J.J. Zhou, D.C. Huang*, Y.F. Li, Z.X. Wang, B. Dong, H.S. Qiao*, W. Chen*, Inherently Nitric Oxide Containing Polymersomes Remotely Regulated by NIR for Improving Multi-Modal Therapy on Drug Resistant Cancer, Biomaterials 2021, 277, 121118.

8. Y.N. Zhong*, J.G. Zhang, J.M. Zhang, Y. Hou, E.P. Chen, D.C. Huang, W. Chen*, R. Haag*, Tumor Microenvironment-Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy, Adv. Funct. Mater. 2021, 31, 2007544.

9. Q. Zhao#, S.Y. Zhang#, F.C. Wu, D.Y. Li, X.J. Zhang*, W. Chen*, B.S. Xing*, Rational Design of Nanogels for Overcoming the Biological Barriers in Various Administration Routes, Angew. Chem. Int. Ed. 2021, 60, 2-20.

10. Z.X. Tu, I.S. Donskyi, H.S. Qiao, Z.L. Zhu, W.E.S. Unger, C.P.R. Hackenberger, W. Chen*, M. Adeli*, and R. Haag*, Graphene Oxide-Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple-Drug Resistance, Adv. Funct. Mater. 2020, 2000933.

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