智能納米藥物的制備及體内外應用

多功能生物材料用于多種疾病微環境調控及治療

主持國自然青年項目1項，項目名稱：腫瘤微環境介導的可分拆型納米凝膠藥物增強腫瘤滲透和實現聯合治療；批準号：51803238；起止年月：2019.01-2021.12，25 萬元，結題。

主持國自然面上項目1項，項目名稱：級聯靶向核殼可分離納米系統協同抑制原發瘤生長及阻斷轉移微環境形成；批準号：52273162；起止年月：2023.01-2026.12，56萬元，在研。

主持企業橫向合作項目1項，項目名稱：高端藥用輔料合成工藝研發聯合實驗室；起止年月：2021.04起，200萬元，在研。

Junmei Zhang, Guizhi Miao, My Hanh Ta, Bingbing Zhao, Wei Wang, Yanran Xing, Hongliang Qian, Dechun Huang*, Wei Chen*, Yinan Zhong*, Photothermal-controlled NO-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis, J. Control. Release 2024, 371, 16-28.

 Shaohui Xu, Pan Zhang, Isabelle Heing-Becker, Junmei Zhang, Peng Tang, Raju Bej, Sumati Bhatia, Yinan Zhong*, Rainer Haag*, Dual tumor- and subcellular-targeted photodynamic therapy using glucose-functionalized MoS2 nanoflakes for multidrug-resistant tumor ablation, Biomaterials 2022, 290, 121844.

 Yanfei Li^#, Hongliang Qian^#, Xin Huang^#, Xiang Zhou, Bingbing Zhao, Lifen Yang, Jiaxin Chen, Haishi Qiao, Dechun Huang*, Yinan Zhong*, Wei Chen*, Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy, Nano Today 2022, 42, 101381.

 Hongliang Qian^#, Ke Wang^#, Mengtong Lv, Changshun Zhao, Hui Wang, Suchen Wen, Dechun Huang*, Wei Chen*, Yinan Zhong*, Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery, J. Control. Release 2022, 343, 492-505.

Yinan Zhong*, Jianguang Zhang, Junmei Zhang, Yong Hou, Enping Chen, Dechun Huang, Wei Chen*, Rainer Haag*, Tumor microenvironment-activatable nanoenzymes for mechanical remodeling of extracellular matrix and enhanced tumor chemotherapy, Adv. Funct. Mater. 2021, 31, 2007544.