制藥工程學(學碩、學博)


江峰
副教授,碩士生導師
院系:伟德官网下载客户端制藥與環境工程系
招生方向:制藥工程學,生物與醫藥(制藥工程與工藝)
實驗室:江甯校區實驗樓A113
電子郵箱:jiangfeng@cpu.edu.cn
辦公室:江甯校區實驗樓A112
個人簡介

(一)學習和工作經曆:

1999.9-2003.7 武漢工程大學化工與制藥學院制藥工程專業,學士;
2004.9-2009.7 
華南理工大學化學與化伟德官网下载客户端化學工程專業,博士;
2009.7-
今  伟德官网下载客户端制藥與環境工程系任教;
2015.3-2016.3 
美國加州大學洛杉矶分校(UCLA)化學與生物化學系Michael E. Jung教授實驗室,國家公派訪問學者。

(二)教學工作:

1、主講本科生課程《制藥工程制圖》、研究生課程《高等合成技術》和《高等制藥分離工程》。

2、主編教材《制藥工程制圖》和《制藥工程制圖習題集》(第三版,化學工業出版社,2021),參編教材8本。

3、主持校級教改課題:研究生精品課程-《高等合成技術》(2022)、研究生專業學位課程改革項目-《高等合成技術》(2022)、基于“培養解決複雜問題能力”的教學内容和方法改革研究(2021)。

4、作為指導教師榮獲江蘇省第五屆大學生生物醫學工程創新設計競賽三等獎(2024)、“東富龍-國藥工程杯”第十屆全國大學生制藥工程設計競賽三等獎(2022),個人榮獲伟德官网下载客户端微課教學比賽三等獎(2022)和“澳天力獎教金”一等獎(2018)。

5、擔任本科生導師3次,指導大學生創新創業計劃項目11次。

(三)社會兼職:

擔任European Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters等學術期刊審稿人。


研究方向

1)生物活性天然産物的分子優化、虛拟篩選和體内外評價;

2)藥物合成新方法和新工藝研究;

3)基于活性藥物分子開展藥物新劑型和新功能研究。


承擔項目情況
  1. 主持重大新藥創制科技重大專項課題(2019ZX09201001-004-001

  2. 主持江蘇省自然科學基金面上項目(BK20201329

  3. 主持中央高校基本科研業務費專項資金重點項目(2632018ZD01

  4. 主持江蘇省自然科學基金青年基金項目(BK20130648

  5. 主持天然藥物活性組分與藥效國家重點實驗室優秀青年學者基金項目(JKGQ201112

  6. 主持中央高校基本科研業務費專項資金青年項目(JKQ2009007

  7. 主持企業橫向開發課題數項

  8. 參與國家重點研發計劃項目(2017YFD0400402

  9. 參與國家自然科學基金面上項目(81573313

  10. 參與國家自然科學基金面上項目(20976060

  11. 主持和參與企業委托橫向項目數項


代表性科研成果

近來發表的代表性科研論文如下:

  1. Haoyi Yang1, Dongyu Zhang1, Ziyang Yuan1, Haishi Qiao, Zhuolu Xia, Feng Cao*, Yuanyuan Lu*, Feng Jiang*. Novel 4-Aryl-4H-chromene derivative displayed excellent in vivo anti-glioblastoma efficacy as the microtubule-targeting agent. European Journal of Medicinal Chemistry2024, 267, 116205.

  2. Jinhui Lu1, Xiaomeng Zhu1, Meng Zhang1, Xunchan Jiang, Wei Guo*, Feng Jiang*, Feng Cao*. In vitro and in vivo assessment of structural integrity for HPCD complex@Liposome nanocomposites from ocular surface to the posterior segment of the eye. Carbohydrate Polymers2023, 315, 120960.

  3. Chunhua Zhang, Qifan Ding, Zhuolu Xia, Hengyu Wang, Feng Jiang* and Yuanyuan Lu*. Novel Chalcone-Phenazine Hybrids Induced Ferroptosis in U87-MG Cells through Activating Ferritinophagy. Chemistry & Biodiversity2023, 20, e202201117.

  4. Yue Yang1, Yuanyuan Lu1, Chunhua Zhang1, Qianqian Guo, Wenzhou Zhang, Ting Wang, Zhuolu Xia, Jing Liu, Xiangyu Cheng, Tao Xi*, Feng Jiang*, Lufeng Zheng*. Phenazine derivatives attenuate the stemness of breast cancer cells through triggering ferroptosis. Cellular and Molecular Life Sciences2022, 79: 360.

  5. Haojie Lu, Jing Liu, Meizhe Yu, Peili Li, Ruobing Huang, Wenzhen Wu, Zunhan Hu, Yuhong Xiao,* Feng Jiang* and Xiaodong Xing*. Photothermal-enhanced antibacterial and antioxidant hydrogel dressings based on catechol-modified chitosan-derived carbonized polymer dots for effective treatment of wound infection. Biomaterials Science2022, 10, 2692-2705.

  6. Yuanyuan Song#, Ziqi Wang#, Yijing Long, Yang Mao, Feng Jiang*, Yuanyuan Lu*. 2-Alkyl-anthraquinones inhibit Candida albicans biofilm via inhibiting the formation of matrix and hyphae. Research in Microbiologoy,, 2022, 173, 103955.

  7. Yucheng Zhong1, Jing Liu1, Xiangyu Cheng, Hao Zhang, Chunhua Zhang, Zhuolu Xia, Zhongxi Wu, Lu Zhang, Yuting Zheng, Zhanyu Gao, Zhidong Jiang, Zhixiang Wang,Dechun Huang, Yuanyuan Lu*, Feng Jiang*. Design, synthesis and biological evaluations of diverse Michael acceptor-based phenazine hybrid molecules as TrxR1 inhibitors. Bioorganic Chemistry2021, 109, 104736.

  8. Jing Liu+, Fei Ji+, Zhuolu Xia, Chunhua Zhang, Changshun Zhao, Yanfei Li, Xiang Zhou, Dechun Huang, Wei Chen*, Feng Jiang*. Multifunctional nanoaggregates composed of active CPUL1 and a triphenylphosphine derivative for mitochondria-targeted drug delivery and cell imaging. ChemMedChem2021, 16, 1-6.

  9. Dechun Huang, Zhonglin Zhu, Qiming Wang, Beichen Qin, Lin Dai, Feng Jiang, Wei Liu*, Hongliang Qian*. Prediction model, experimental optimization, and verification for yield of high-pressure crystallization: a case study of citric acid. Separation Science and Technology2020,55(1): 135-143.

  10. Jianming Liao, Linlin Wang, Zhongxi Wu, Zhixiang Wang, Jun Chen, Yucheng Zhong, Feng Jiang*, Yuanyuan Lu*. Identification of phenazine analogue as a novel scaffold for thioredoxin reductase I inhibitors against HepG2 cancer cell lines. Journal of Enzyme Inhibition and Medicinal Chemistry2019, 34(1): 1158-1163.

  11. Meichen Zhang, Shuhui Gu, Guangpan Liu, Chencheng Li, Hanmei Xu*, Zhongxi Wu, Boping Ye, Yuanyuan Lu, Dechun Huang, Zhixiang Wang, Feng Jiang*. Facile synthesis and cytotoxicity of phenazine-chromene hybrid molecules derived from phenazine natural product. Combinatorial Chemistry & High Throughput Screening2019, 22(1): 35-40.

  12. Jing Zhang, Qiming Wang, Zhonglin Zhu, Hongliang Qian, Feng Jiang, Zhixiang Wang, Wei Liu*, Dechun Huang*. Micronization of gefitinib using solution‐enhanced dispersion by supercritical CO2Chemical Engineering & Technology2019, 42(2): 388-396.

  13. Hongliang Qian, Lin Dai, Feng Jiang, Yiqiang Shi, Zhixiang Wang, Wei Liu*, Dechun Huang*, Wei Chen. Quantitative design of seed load based on model identification of nucleation and crystal growth stages without transmittance data. Powder Technology2018, 335, 11-17.

  14. Yuanyuan Lu, Yuru Yan, Linlin Wang, Xiaobing Wang, Jing Gao, Tao Xi, Zhixiang Wang, Feng Jiang*. Design, facile synthesis and biological evaluations of novel pyrano[3,2-a]phenazine hybrid molecules as antitumor agents. European Journal of Medicinal Chemistry2017, 127, 928-943.

  15. Yuanyuan Lu*, Linlin Wang, Xiaobing Wang, Tao Xi, Jianmin Liao, Zhixiang Wang, Feng Jiang*. Design, combinatorial synthesis and biological evaluations of novel 3-amino-1′-((1-aryl-1H-1,2,3-triazol-5-yl)methyl)-2′-oxospiro[benzo[a] pyrano[2,3-c]phenazine-1,3′-indoline]-2-carbonitrile antitumor hybrid molecules. European Journal of Medicinal Chemistry2017, 135, 125-141.


授權發明專利如下:

  1. 江峰王榮劉靜等二硫鍵修飾的納米聚集體及其制備方法和應用中國發明專利2022111500513.

  2. 江峰夏卓璐張東宇等吡喃并喹啉衍生物及其制備方法和應用中國發明專利2022106500674.

  3. 江峰王榮陸園園等一種查爾酮吩嗪雜化分子及其應用中國發明專利2022106290021.

  4. 江峰劉靜黃德春等一種納米聚集體及其制備方法和應用中國發明專利2021109114648.

  5. 陸園園丁啟帆江峰. CPUL1脂質體及其制備方法中國發明專利2021104939593.

  6. 江峰吳仲稀王志祥等作為TrxR1抑制劑的吩嗪衍生物、中間産物及其制備方法和用途中國發明專利2019104264957.

  7. 江峰闫玉茹陸園園等一種吡喃并[3,2-a]吩嗪衍生物及其制備方法和用途中國發明專利2015108940700.


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