章翔宇,伟德官网下载客户端生物醫學工程與診斷藥學系講師,碩士研究生導師。博士畢業于英國倫敦大學學院(University College London,UCL),師從Jim Anderson教授(FRSC)。2020年加入伟德官网下载客户端伟德官网下载客户端從事教學科研工作。
主要研究方向:
1. 複雜天然産物和手性藥物的全合成研究和工藝開發,聚焦具有多種藥理活性的複雜生物堿、前列腺素類高活性藥物的工藝研究與創新衍生;
2. 靶向藥物/分子探針的設計、合成與生物學活性評價
獲江蘇省“雙創博士”,主持國家自然科學基金青年項目一項、參與面上項目一項,中央高校基本科研業務經費重點項目一項;
在Angew. Chem. Int. Ed. (IF 16.6)、 Nat. Prod. Rep. (IF 11.9)、 J. Med. Chem. (IF 7.3)、Eur. J. Med. Chem. (IF 6.7) 等專業學術期刊發表學術論文多篇。
2024年招生專業:制藥工程(學術型)
代表性論文:
1.X. Zhang, Vallesamidine and schizozygane alkaloids: rearranged monoterpene indole alkaloids and synthetic endeavours. Nat. Prod. Rep.2024, Advance Article (DOI:10.1039/d3np00048f)
2.K. Wang‡, X. Zhang‡, Y. Cheng, Z. Qi, K. Ye, K. Zhang, S. Jiang, Y. Liu, Y. Xiao, T. Wang, Discovery of Novel PD-L1 Inhibitors That Induce the Dimerization, Internalization, and Degradation of PD-L1 Based on the Fragment Coupling Strategy. J. Med. Chem.2023, 66, 16807.
3.T. Wang‡, K. Wang‡, Y. Zhang, K.Zhang, S. Cai, S. Jiang*, Y. Xiao*, X. Zhang*, Novel Benzimidazoles as Potent Small-Molecule Inhibitors and Degraders of V‐Domain Ig Suppressor of T‐Cell Activation (VISTA). J. Med. Chem.2023, 66, 11881.
4.K.Zhang, T, Wang, M. Li, M. Liu, H. Tang, L. Wang, K. Ye, J. Yang, S. Jiang, Y. Xiao, Y. Xie*, M. Lu*, X.Zhang*, Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro). Eur. J. Med. Chem.2023, 257, 115487.
5.X.Zhang, J. C. Anderson*, A Divergent Synthetic Route to the Vallesamidine and Schizozygine Alkaloids: Total Synthesis of (+)-Vallesamidine and (+)-14,15-Dehydrostrempeliopine. Angew. Chem. Int. Ed.2019, 58, 18040.